A web resource for mining HLA associations with adverse drug reactions: HLA-ADR Database
(Oxford). 2016
Full textThe HLA Adverse Drug Reaction Database (HLA-ADR)
The HLA and Adverse Drug Reaction Database (HLA-ADR) is part of the Allele Frequencies Net Database (AFND). HLA-ADR captures data from publications where HLA alleles and haplotypes have been associated with ADRs (e.g. Stevens–Johnson Syndrome/toxic epidermal necrolysis and drug-induced liver injury). HLA-ADR was created by using data obtained through systematic review of the literature and semi-automated literature mining. The database also draws on data already present in AFND allowing users to compare and analyze allele frequencies in both ADR patients and healthy populations.
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| Database Information | Total |
|---|---|
| HLA alleles in database | 318 |
| Drugs present in database | 48 |
| HLA-ADR association records | 1945 |
| Published studies | 120 |